Bioprocess Consulting Services
Optimizing the Physics of Scale-Up
We bridge the gap between laboratory benchtop success and commercial-scale production. Our models address fluid dynamics and mass transfer constraints before you commit to hardware runs.
Scale-Up
Engineering constraints that shape scale-up success.
Fluid Dynamics
Mixing patterns, circulation zones, velocity distribution.
Mass Transfer
Oxygen transfer, aeration strategy, transport limits.
Shear Stress
Impeller impact, sparging stress, energy dissipation.
Cell Tolerance
Assessing stress on sensitive mammalian or stem cells.
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Upstream development from bench to pilot scale
We deploy precise engineering calculations and systematic experimental designs to optimize every phase of your cell culture process.
Bioprocess Development
Scale-Up & Tech Transfer
Troubleshooting & Training
Optimize bioreactor strategy, media formulation, and feeding regimens to maximize specific productivity and product quality.
De-risk vessel transition through fluid dynamics modeling, mass transfer analysis, and vessel geometry characterization.
Resolve sudden yield drop-offs, optimize experimental designs, and train operations teams on advanced bioreactor systems.
De-risking transfer through physics
Yield Doubled in 50L Vessel
Zero-Loss CDMO Onboarding
We resolved shear-stress limitations for a clinical-stage therapy client by modeling impeller geometry and optimizing agitation rates, preventing cell damage during scale transition.
Using precise mass transfer coefficient matching, we transferred a complex monoclonal antibody process from laboratory benchtop to a European CDMO facility without yield drop.
2.4x
Viable Cell Density Increase
14 days
Saved from Trial-and-Error Runs
Planning a Scale-Up or Troubleshooting a Bioreactor Process?
AMSP can support your team with engineering insight, process interpretation, and scale-up strategy before you commit to major experimental or hardware decisions.