Optimizing the physics of *scale-up*
AMSP provides rigorous scientific consulting to de-risk upstream tech transfer, characterize bioreactor geometries, and maximize metabolic yield for complex biopharma and stem cell processes.
We bridge the gap between laboratory benchtop success and commercial-scale production. Our models address fluid dynamics and mass transfer constraints before you commit to hardware runs.
Upstream development from bench to pilot scale
We deploy precise engineering calculations and systematic experimental designs to optimize every phase of your cell culture process.
Bioprocess Development
Scale-Up & Tech Transfer
Troubleshooting & Training
Optimize bioreactor strategy, media formulation, and feeding regimens to maximize specific productivity and product quality.
De-risk vessel transition through fluid dynamics modeling, mass transfer analysis, and vessel geometry characterization.
Resolve sudden yield drop-offs, optimize experimental designs, and train operations teams on advanced bioreactor systems.
De-risking transfer through physics
Yield Doubled in 50L Vessel
Zero-Loss CDMO Onboarding
We resolved shear-stress limitations for a clinical-stage therapy client by modeling impeller geometry and optimizing agitation rates, preventing cell damage during scale transition.
Using precise mass transfer coefficient matching, we transferred a complex monoclonal antibody process from laboratory benchtop to a European CDMO facility without yield drop.
2.4x
Viable Cell Density Increase
14 days
Saved from Trial-and-Error Runs
Ready to optimize your upstream process?
Connect with our principal engineers to discuss vessel characterization, data modeling, or local AI scale-up integration.